Phospholipase A2Type II Binds to Extracellular Matrix Biglycan

Phospholipase A2 type II binds to extracellular matrix biglycan: modulation of its activity on LDL by colocalization in glycosaminoglycan matrixes.

We recently reported the presence of secretory, nonpancreatic phospholipase A2 type II (snpPLA2; EC 3.1.1.4) in human atherosclerotic arteries (Hurt-Camejo et al, Arterioscler Thromb Vasc Biol. 1997;17:300-309). SnpPLA2 may generate the proinflammatory products lysophospholipids and free fatty acids, thus contributing to atherogenesis when acting on low density lipoproteins (LDLs) retained in t...

WISP-1 binds to decorin and biglycan.

Wnt-1-induced secreted protein 1 (WISP-1) is a member of the CCN (connective tissue growth factor, Cyr61, NOV) family of growth factors. Structural and experimental evidence suggests that CCN family member activities are modulated by their interaction with sulfated glycoconjugates. To elucidate the mechanism of action for WISP-1, we characterized the specificity of its tissue and cellular inter...

Proteoglycans Decorin and Biglycan with Interactions of the Extracellular Matrix

Secretory type II phospholipase A binds to ischemic myocardium

Objective: An increase of circulating secretory Phospholipase A (sPLA ) is a risk factor for coronary artery disease. We hypothesized 2 2 that this reflects participation of sPLA in local inflammatory reactions ensuing in ischemic myocardium. Therefore, we studied the course 2 of circulating sPLA , in patients with acute myocardial infarction (AMI) or unstable angina pectoris (UAP), and investi...

Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis.

Retention of lipoproteins to proteoglycans in the subendothelial matrix (SEM) is an early event in atherosclerosis. We recently reported that collagen XVIII and its proteolytically released fragment endostatin (ES) are differentially depleted in blood vessels affected by atherosclerosis. Loss of collagen XVIII/ES in atherosclerosis-prone mice enhanced plaque neovascularization and increased the...